Motif ID: RXRA_VDR{dimer}.p2

Z-value: 0.495


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
VDR 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VDRchr12_-_48298765-0.049.2e-01Click!


Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_175036993 0.244 NM_022093
TNN
tenascin N
chr11_-_63933204 0.223 MACROD1
MACRO domain containing 1
chr16_+_19078958 0.187 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr1_+_229406835 0.178 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr2_+_230787195 0.177 NM_174899
FBXO36
F-box protein 36
chr6_-_68598987 0.176 ERVH-3
endogenous retrovirus group H, member 3
chr14_-_34419957 0.166 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr11_+_124609841 0.162 NRGN
neurogranin (protein kinase C substrate, RC3)
chr19_-_44008984 0.153 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr19_-_58858900 0.139 A1BG
alpha-1-B glycoprotein
chr1_+_61869699 0.137 NFIA
nuclear factor I/A
chr16_+_19078916 0.136 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr4_+_134073180 0.134 PCDH10
protocadherin 10
chr14_+_95047730 0.132 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr12_-_109251333 0.129 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr3_-_27764197 0.128 EOMES
eomesodermin
chr16_+_19079220 0.127 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr9_-_77643156 0.125 C9orf41
chromosome 9 open reading frame 41
chr6_-_167040700 0.120 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_+_203764802 0.117 ZC3H11A
zinc finger CCCH-type containing 11A
chr10_+_35484829 0.113 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr12_-_105627182 0.112 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr1_-_1850704 0.112 NM_178545
TMEM52
transmembrane protein 52
chr2_+_238768186 0.111 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr10_+_102732285 0.109 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr1_+_161284165 0.108 NM_001035511
NM_001035512
NM_001035513
NM_003001
SDHC



succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa



chr17_+_2699731 0.107 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr19_-_14260728 0.106 LPHN1
latrophilin 1
chr1_-_154943001 0.104 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr9_+_140125208 0.101 NM_001177316
NM_001177317
SLC34A3

solute carrier family 34 (sodium phosphate), member 3

chr17_+_75447325 0.098 SEPT9
septin 9
chr17_-_39222126 0.097 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr21_-_35986744 0.097 NM_203417
RCAN1
regulator of calcineurin 1
chr11_-_67188614 0.095 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr6_+_31802644 0.091 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr16_+_31119730 0.086 BCKDK
branched chain ketoacid dehydrogenase kinase
chr16_+_77756388 0.086 NM_001105663
NM_001243657
NM_001243660
NM_001243661
NUDT7



nudix (nucleoside diphosphate linked moiety X)-type motif 7



chr19_+_1383877 0.085 NM_024407
NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr6_-_167040506 0.082 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr20_+_18568541 0.078 NM_080820
DTD1
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
chr16_+_31119661 0.077 NM_001122957
NM_005881
BCKDK

branched chain ketoacid dehydrogenase kinase

chr19_+_1383898 0.077 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr3_+_190105660 0.076 NM_006580
CLDN16
claudin 16
chr12_-_6579754 0.073 NM_014231
NM_016830
NM_199245
VAMP1


vesicle-associated membrane protein 1 (synaptobrevin 1)


chr19_+_1383904 0.072 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chr19_+_7985193 0.071 NM_003083
SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr1_-_3816823 0.070 NM_207356
C1orf174
chromosome 1 open reading frame 174
chr19_+_41620336 0.070 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr19_+_39899749 0.069


chr17_-_79791152 0.068 NM_001093767
NM_207368
FAM195B

family with sequence similarity 195, member B

chr14_-_51561657 0.068 TRIM9
tripartite motif containing 9
chr14_-_101034261 0.067 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr7_-_44365019 0.066 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr16_+_31044849 0.065 STX4
syntaxin 4
chr14_+_95047758 0.065 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr19_+_56186426 0.065 NM_001130072
NM_013333
EPN1

epsin 1

chr16_+_28889808 0.064 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr19_+_36630999 0.064 CAPNS1
calpain, small subunit 1
chr6_+_69344939 0.064 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr11_-_5701371 0.063 TRIM5
tripartite motif containing 5
chr15_+_83776323 0.063 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr1_-_27732069 0.063 WASF2
WAS protein family, member 2
chr11_+_65407591 0.062 NM_153253
SIPA1
signal-induced proliferation-associated 1
chrX_+_106161589 0.062 NM_001171095
CLDN2
claudin 2
chr20_+_37590969 0.062 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr11_+_64863711 0.062 C11orf2
chromosome 11 open reading frame 2
chr3_+_38032260 0.062 VILL
villin-like
chr17_-_43045612 0.062 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr11_+_64863607 0.062 NM_013265
C11orf2
chromosome 11 open reading frame 2
chr11_+_64863700 0.061 C11orf2
chromosome 11 open reading frame 2
chr7_+_91763851 0.060 LOC613126
uncharacterized LOC613126
chr2_+_220363536 0.059 NM_013335
NM_205847
GMPPA

GDP-mannose pyrophosphorylase A

chr11_-_124806302 0.059 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr19_+_36631001 0.056 CAPNS1
calpain, small subunit 1
chr6_-_167040659 0.056 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_-_124805896 0.056 HEPACAM
hepatic and glial cell adhesion molecule
chr17_-_56609361 0.055 SEPT4
septin 4
chr3_+_49208979 0.055 NM_173546
KLHDC8B
kelch domain containing 8B
chr2_+_233498206 0.054 NM_025202
EFHD1
EF-hand domain family, member D1
chr1_-_3816704 0.053 C1orf174
chromosome 1 open reading frame 174
chr20_+_34680569 0.053 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr18_+_46065367 0.052 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr6_+_35227478 0.050 NM_003427
ZNF76
zinc finger protein 76
chr9_-_140317650 0.050 EXD3
exonuclease 3'-5' domain containing 3
chr19_+_56186580 0.049 EPN1
epsin 1
chr11_-_64084980 0.049 NM_016404
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr5_-_63257959 0.049 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr14_-_93581507 0.049 ITPK1
inositol-tetrakisphosphate 1-kinase
chr6_-_91006580 0.048 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr18_-_32924417 0.048 NM_006965
ZNF24
zinc finger protein 24
chr18_-_6414900 0.048 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr11_+_36616039 0.048 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr10_-_43892160 0.048 NM_001098208
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr11_+_60869929 0.048 NM_014207
CD5
CD5 molecule
chr19_+_50270068 0.047 NM_014203
NM_130787
AP2A1

adaptor-related protein complex 2, alpha 1 subunit

chr19_+_19322763 0.047 NM_004386
NCAN
neurocan
chr5_-_179051586 0.047 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_+_45409003 0.047 NM_000041
APOE
apolipoprotein E
chr11_-_16996559 0.047 RPL36A
ribosomal protein L36a
chr6_-_32145841 0.046 NM_032741
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr1_+_203764822 0.046 ZC3H11A
zinc finger CCCH-type containing 11A
chr6_-_42016383 0.045 CCND3
cyclin D3
chr6_-_91006460 0.045 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_-_175712669 0.045 NM_003285
TNR
tenascin R (restrictin, janusin)
chr3_+_13521714 0.045 NM_024827
NM_001136041
HDAC11

histone deacetylase 11

chr16_+_31119748 0.044 BCKDK
branched chain ketoacid dehydrogenase kinase
chr4_+_1902352 0.044 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr4_-_122872908 0.044 NM_001130698
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr19_-_13068033 0.043 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr10_-_43892697 0.042 NM_001098207
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr3_+_132036276 0.042 ACPP
acid phosphatase, prostate
chr11_+_128563772 0.042 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr5_-_32174397 0.042 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr15_-_89764809 0.042 NM_000326
RLBP1
retinaldehyde binding protein 1
chr21_-_30391597 0.041 NM_016940
RWDD2B
RWD domain containing 2B
chr1_-_209979388 0.041 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr19_-_18654280 0.040 FKBP8
FK506 binding protein 8, 38kDa
chr1_+_110527701 0.040 AHCYL1
adenosylhomocysteinase-like 1
chr1_-_23751126 0.040 NM_003196
TCEA3
transcription elongation factor A (SII), 3
chr4_+_6675798 0.039 LOC93622
Morf4 family associated protein 1-like 1 pseudogene
chr3_-_27763784 0.039 NM_005442
EOMES
eomesodermin
chr14_+_105780751 0.039 NM_001100913
NM_015197
PACS2

phosphofurin acidic cluster sorting protein 2

chr6_+_27215479 0.038 NM_005865
PRSS16
protease, serine, 16 (thymus)
chr22_+_50624353 0.038 NM_025204
TRABD
TraB domain containing
chr4_+_6675654 0.038 LOC93622
Morf4 family associated protein 1-like 1 pseudogene
chr19_+_13250072 0.038 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr11_+_63997752 0.038 NM_005528
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr19_-_18654376 0.038 NM_012181
FKBP8
FK506 binding protein 8, 38kDa
chr17_+_7123149 0.038 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr19_+_56186610 0.038 EPN1
epsin 1
chr12_-_95397455 0.038 NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr5_-_32174327 0.038 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr2_-_25194772 0.037 NM_001198559
NM_016544
DNAJC27

DnaJ (Hsp40) homolog, subfamily C, member 27

chr19_-_5903991 0.037 NM_001193375
NM_175614
NDUFA11

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa

chr8_+_99956630 0.037 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr9_-_140317713 0.036 NM_017820
EXD3
exonuclease 3'-5' domain containing 3
chr17_-_76778306 0.036 NM_004762
NM_017456
CYTH1

cytohesin 1

chr19_+_56186569 0.036 EPN1
epsin 1
chr17_-_74068576 0.036 SRP68
signal recognition particle 68kDa
chr21_+_45161343 0.035 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr22_-_30867944 0.035 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr5_-_32174385 0.035 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr22_+_39077979 0.035 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr14_+_95047792 0.035 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr9_+_102668904 0.035 NM_017919
STX17
syntaxin 17
chr5_-_32174355 0.034 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr19_-_13068008 0.034 GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr12_-_53171104 0.034 NM_015848
KRT76
keratin 76
chr12_+_70172748 0.034 NM_001024647
RAB3IP
RAB3A interacting protein (rabin3)
chr7_+_143078457 0.034 ZYX
zyxin
chr9_+_102668953 0.033 STX17
syntaxin 17
chr19_+_36630846 0.033 NM_001003962
NM_001749
CAPNS1

calpain, small subunit 1

chr12_-_95397487 0.032 NM_018838
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr16_-_4292052 0.032 NM_001098814
SRL
sarcalumenin
chr11_-_77791264 0.031 NM_001203260
NM_001203261
NM_001203262
NM_001204054
NM_001204055
NM_004549
NDUFC2-KCTD14


NDUFC2


NDUFC2-KCTD14 readthrough


NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa


chr1_-_46152183 0.031 NM_021639
GPBP1L1
GC-rich promoter binding protein 1-like 1
chr19_+_13056656 0.031 RAD23A
RAD23 homolog A (S. cerevisiae)
chrX_-_109683457 0.031 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr19_+_7985884 0.031 SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr15_+_91428271 0.030 NM_001143783
NM_001143784
FES

feline sarcoma oncogene

chr19_+_50270271 0.030 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr10_-_43892675 0.030 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr6_-_42016609 0.030 NM_001136017
NM_001136126
CCND3

cyclin D3

chr7_+_143078444 0.030 ZYX
zyxin
chr22_+_39077953 0.030 NM_020243
TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr5_-_32174242 0.030 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr1_+_203764750 0.029 NM_014827
ZC3H11A
zinc finger CCCH-type containing 11A
chr1_+_110527432 0.029 AHCYL1
adenosylhomocysteinase-like 1
chr10_-_45496259 0.029 NM_001039380
C10orf25
chromosome 10 open reading frame 25
chr21_-_47575472 0.029 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr17_-_7123368 0.028 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr19_-_47987475 0.028 NM_007059
KPTN
kaptin (actin binding protein)
chr11_-_66084501 0.028 NM_020404
CD248
CD248 molecule, endosialin
chr14_+_24584467 0.028 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr20_+_62372436 0.028 SLC2A4RG
SLC2A4 regulator
chr1_+_229407015 0.028 RAB4A
RAB4A, member RAS oncogene family
chr14_-_65289812 0.027 NM_000347
NM_001024858
SPTB

spectrin, beta, erythrocytic

chr7_+_143078358 0.027 NM_001010972
NM_003461
ZYX

zyxin

chr1_-_153585504 0.027 NM_080388
S100A16
S100 calcium binding protein A16
chr2_-_80530943 0.027 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr17_-_41977966 0.027 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr22_+_39077960 0.027 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr19_+_42817434 0.026 NM_173633
TMEM145
transmembrane protein 145
chr17_+_18380097 0.026 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr22_+_39077975 0.026 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr16_+_2255423 0.026 MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr11_-_32456910 0.026 WT1
Wilms tumor 1
chr19_-_47987410 0.026 KPTN
kaptin (actin binding protein)
chr16_+_31044881 0.024 NM_004604
STX4
syntaxin 4
chr2_+_113341999 0.024 NM_032309
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr10_+_134351272 0.024 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr19_-_19007395 0.023 CERS1
ceramide synthase 1
chr14_+_24439082 0.023 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr20_+_30028410 0.023 NM_153324
DEFB123
defensin, beta 123
chr18_+_48086402 0.023 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr11_+_46639112 0.023 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr19_+_13056671 0.023 RAD23A
RAD23 homolog A (S. cerevisiae)
chr1_+_145663156 0.023 RNF115
ring finger protein 115
chr10_+_111767877 0.023 ADD3
adducin 3 (gamma)
chr18_-_59560303 0.022 NM_173557
RNF152
ring finger protein 152

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.41 4.36e-03 GO:0015980 energy derivation by oxidation of organic compounds
4.52 1.71e-02 GO:0045333 cellular respiration

Nothing significant found in compartment category.

Nothing significant found in function category.